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Ki67%
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
Neutrophil-to-lymphocyte ratio (NLR)
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
Primary tumor location
Pancreas, stomach
Colorectal
Unknown
Small intestine
Hepatic burden disease
No liver metastases
>0−24%
25−50%
>50%
Peritoneal metastases
Bone metastases
Alkaline phosphatase
Normal
1.1-2.5 ULN
>2.5 ULN
Documented progression status prior to SSA
Stable disease not documented, or <3 months
Stable disease for ≥3 months
Tumor progression
Symptoms from the tumor
No symptoms
Tumor or endocrine-related symptoms
Clear
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Predictions are only orientative, and often approximate, so decisions should be taken at the discretion of the attending physician. In particular, clinical trials have included only patients with Ki67% up to 10%. Therefore, predictions based on proliferation indices greater than 10% may be subject to more uncertainty, and be overestimated.
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